-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	572981
标题:	Synthesis and biological evaluation of substituted alpha-methyl-3-(trifluoromethyl)benzeneethanamine derivatives as novel N-type calcium channel blockers
作者:	Warmus, J.; Weber, M.l.; Stoehr, S.; Downing, D.; Kornberg, B.E.; Rock, D.M.; Rafferty, M.F.; Szoke, B.G.; Nikam, S.S.
来源:	219th ACS Natl Meet (March 26 2000, San Francisco) 2000,Abst MEDI 260

合成路线图解说明: The title urea derivative was obtained by condensation of 2,6-diisopropylphenyl isocyanate (I) with alpha-methyl-3-(trifluoromethyl)phenylethyl amine (II) in the presence of Et3N, followed by treatment with potassium sarcosinate as isocyanate scavenger.