Rec-2615, Rec-15/2615-药物合成数据库

【药物名称】Rec-2615, Rec-15/2615

化学结构式(Chemical Structure):

参考文献No.	28040
标题:	Quinazolinyl-amino derivs. having alpha-antagonist activity
作者:	Leonardi, A.; Motta, G.; Boi, C.; Testa, R. (Recordati Industria Chimica e Farmaceutica SpA)
来源:	EP 0750614; JP 1997511238; US 5798362; WO 9525726

合成路线图解说明: The alkylation of 2-isopropyl-6-methoxyphenol (I) with ethyl bromoacetate (II) under phase-transfer conditions in the presence of NaOH provided (aryloxy)acetic acid (III) which, upon treatment with SOCl2, was converted into acid chloride (IV). Coupling of (IV) with 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (V) then furnished the target amide. The title compound was finally isolated as the hydrochloride salt.

参考文献No.	574657
标题:	Synthesis, pharmacological evaluation, and structure-activity relationship and quantitative structure-activity relationship studies on novel derivatives of 2,4-diamino-6,7-dimethoxyquinazoline alpha1-adrenoceptor antagonists
作者:	Leonardi, A.; Motta, G.; Boi, C.; Testa, R.; Poggesi, E.; De Benedetti, P.G.; Menziani, M.C.
来源:	J Med Chem 2000,42(3),427

合成路线图解说明: The alkylation of 2-isopropyl-6-methoxyphenol (I) with ethyl bromoacetate (II) under phase-transfer conditions in the presence of NaOH provided (aryloxy)acetic acid (III) which, upon treatment with SOCl2, was converted into acid chloride (IV). Coupling of (IV) with 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (V) then furnished the target amide. The title compound was finally isolated as the hydrochloride salt.