【药物名称】NSC-672121
化学结构式(Chemical Structure):
参考文献No.42838
标题:Antiproliferative naphthoquinones, derivs., compsns., and uses thereof
作者:Kerns, J.K.; Carr, B.I.; Wilcox, C.S. (University of Pittsburgh)
来源:WO 0008495
合成路线图解说明:

Halogenation of vitamin K3 (menadione) (I) by means of bromine and NaOAc in AcOH furnished 3-bromo menadione (II). Subsequent displacement of the halogen of (II) by 2-mercaptoethanol (III) in the presence of imidazole yielded the desired (2-hydroxyethyl) thioether.

参考文献No.573530
标题:Thioalkyl derivatives of vitamin K3 and vitamin K3 oxide inhibit growth of Hep3B and HepG2 cells
作者:Kerns, J.; Carr, B.; Dowd, P.; Finn, F.M.; Naganathan, s.
来源:Bioorganic Chemistry 1995,23(2),101
合成路线图解说明:

In an alternative procedure, the title compound was obtained by addition of 2-mercaptoethanol (III) to vitamin K3 oxide (menadione oxide) (IV) in the presence of imidazole.

参考文献No.641376
标题:Synthesis of protein tyrosine phosphatase inhibitor and application for malignant pediatric tumor
作者:Horikawa, A.; et al.
来源:21st Symp Med Chem (Nov 28 2001, Kyoto) 2001,Abst 2P-05
合成路线图解说明:

In an alternative procedure, the title compound was obtained by addition of 2-mercaptoethanol (III) to vitamin K3 oxide (menadione oxide) (IV) in the presence of imidazole.

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