C-75-药物合成数据库

【药物名称】C-75

化学结构式(Chemical Structure):

参考文献No.	43617
标题:	Inhibition of fatty acid synthase as a means to reduce adipocyte mass
作者:	Kuhajda, F.P.; Mani, N.S.; Pasternack, G.R.; Townsend, C.A. (Johns Hopkins University)
来源:	WO 9718806

合成路线图解说明: p-Methoxybenzyl itaconate (III) was prepared by reaction of itaconic anhydride (I) with p-methoxybenzyl alcohol (II) at 55-60 C (1). Condensation of the lithium enolate of (III) with nonanal (IV) in THF at -78 C gave adduct (V), which upon treatment with trifluoroacetic acid underwent cyclization and benzyl ester deprotection to yield the corresponding butyrolactone as a diastereomeric mixture. The major trans isomer was finally isolated by flash chromatography.

参考文献No.	570857
标题:	Syntesis and antitumor activity of an inhibitor fatty acid synthase
作者:	Kuhajda, F.P.; Pizer, E.S.; Li, J.N.; Mani, N.S.; Frehywot, G.; Townsend, G.A.
来源:	Proceedings of the National Academy of Sciences of the United States of America 2000,97(7),3450

合成路线图解说明: p-Methoxybenzyl itaconate (III) was prepared by reaction of itaconic anhydride (I) with p-methoxybenzyl alcohol (II) at 55-60 C (1). Condensation of the lithium enolate of (III) with nonanal (IV) in THF at -78 C gave adduct (V), which upon treatment with trifluoroacetic acid underwent cyclization and benzyl ester deprotection to yield the corresponding butyrolactone as a diastereomeric mixture. The major trans isomer was finally isolated by flash chromatography.