SC-22716-药物合成数据库

【药物名称】SC-22716

化学结构式(Chemical Structure):

参考文献No.	569000
标题:	Structure-activity relationship studies on 1-[2-(4-phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A4 (LTA4) hydrolase
作者:	Penning, T.D.; Chandrakumar, N.S.; Chen, B.B.; Chen, H.Y.; Desai, B.N.; Djuric, S.W.; Docter, S.H.; Gasiecki, A.F.; Haack, R.A.; Miyashiro, J.M.; Russell, M.A.; Yu, S.S.; Corley, D.G.; Durley, R.C.; Kilpatrick, B.F.; Parnas, B.L.; Askonas, L.J.; et al.
来源:	J Med Chem 2000,43(3),721

合成路线图解说明: The title compound was prepared by alkylation of 4-phenylphenol (I) with 1-(2-chloroethyl)pyrrolidine.HCl (II) in the presence of NaH in hot DMF.