【药物名称】
化学结构式(Chemical Structure):
参考文献No.567380
标题:Synthesis and antitumor activities of 5-methyl-1- and 2-[[2-dimethylaminoethyl]amino]-aza-thiopyranoindazoles
作者:Krapcho, A.P.; Haydar, S.N.; Truong-Chiott, S.; Hacker, M.P.; Menta, E.; Beggiolin, G.
来源:Bioorg Med Chem Lett 2000,10(3),305
合成路线图解说明:

Condensation of 4-chloronicotinic acid (I) with 5-chloro-2-methylthiophenol (II) led to thioether (III). Treatment of (III) with thionyl chloride, followed by Friedel-Crafts cyclization of the resulting acid chloride (IV) with AlCl3 in nitrobenzene at 100 C afforded the tricyclic compound (V). Finally, heating of (V) with N-(2-dimethylaminoethyl)hydrazine (VI) furnished the title compound.

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