【药物名称】L-756423
化学结构式(Chemical Structure):
参考文献No.37906
标题:Sulfate salt of an HIV protease inhibitor having an improved oral absorption and bioavailability
作者:Hoerrner, R.S.; Volante, R.P.; Purick, R.M.; Askin, D.; Reider, P.; Varsolona, R.J. (Merck & Co., Inc.)
来源:EP 0986554; JP 2000513747; US 6071916; WO 9854178
合成路线图解说明:

Compound (I) (intermediate no. (VIII) in scheme no. 19918301a) is a key intermediate in the synthesis of indinavir. For the synthesis of the product 285239, (I) is coupled with benzofuran-2-carbaldehyde (II) via a reductive amination by means of NaBH(OAc)3 either in 1,2-dichloroethane/AcOH or in isopropyl acetate/AcOH.

参考文献No.39605
标题:Combination therapy for the treatment of AIDS
作者:Lin, J.H.; Chodakewitz, J.A.; Deutsch, P.J.; Vacca, J.P.; Yeh, K.C.; Ju, W.D. (Merck & Co., Inc.)
来源:WO 9925352
合成路线图解说明:

Compound (I) (intermediate no. (VIII) in scheme no. 19918301a) is a key intermediate in the synthesis of indinavir. For the synthesis of the product 285239, (I) is coupled with benzofuran-2-carbaldehyde (II) via a reductive amination by means of NaBH(OAc)3 either in 1,2-dichloroethane/AcOH or in isopropyl acetate/AcOH.

参考文献No.589310
标题:Identification of MK-944a: A second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors
作者:Dorsey, B.D.; McDonough, C.; McDaniel, S.L.; Levin, R.B.; Newton, C.L.; Hoffman, J.M.; Darke, P.L.; Zugay-Murphy, J.A.; Emini, E.A.; Schleif, W.A.; Olsen, D.B.; Stahlhut, M.W.; Rutkowski, C.A.; Kuo, L.C.; Lin, J.H.; Chen, I.W.; Michelson, S.R.; et al.
来源:J Med Chem 2000,43(18),3386
合成路线图解说明:

Compound (I) (intermediate no. (VIII) in scheme no. 19918301a) is a key intermediate in the synthesis of indinavir. For the synthesis of the product 285239, (I) is coupled with benzofuran-2-carbaldehyde (II) via a reductive amination by means of NaBH(OAc)3 either in 1,2-dichloroethane/AcOH or in isopropyl acetate/AcOH.

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