【药物名称】
化学结构式(Chemical Structure):
参考文献No.562954
标题:Synthesis of beta-substituted naphth-1-yl ethylamido derivatives as new melatoninergic agonists
作者:Math?Allainmat, M.; le Gall, M.; Jellimann, C.; Andrieux, J.; Langlois, M.
来源:Bioorg Med Chem 1999,7(12),2945
合成路线图解说明:

Alkylation of (7-methoxy-1-naphthyl)acetonitrile (I) with iodomethane in the presence of NaH gave the corresponding naphthylpropionitrile (II), which was reduced to amine (III) by catalytic hydrogenation over Raney-Ni. Finally, condensation of (III) with butyryl chloride in the presence of triethylamine provided the title butyramide.

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