【药物名称】
化学结构式(Chemical Structure):
参考文献No.562711
标题:Synthesis and SAR of 4-aryl-2-hydroxy-4-oxobut-2-enoic acids esters and 2-amino-4-aryl-4-oxobut-2-enoic acids and esters: Potent inhibitors of kynurenine-3-hydroxylase as potential neuroprotective agents
作者:Drysdale, M.J.; Hind, S.L.; Janssen, M.; Reinhard, J.F. Jr.
来源:J Med Chem 2000,43(1),123
合成路线图解说明:

By condensation of 3-chloroacetophenone (I) with dimethyl oxalate (II) by means of NaOMe in methanol.

合成路线图解说明:

By condensation of 3-fluoroacetophenone (I) with dimethyl oxalate (II) by means of NaOMe in methanol.

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