L-708906-药物合成数据库

【药物名称】L-708906

化学结构式(Chemical Structure):

参考文献No.	41397
标题:	HIV integrase inhibitors
作者:	Guare, J.P. Jr.; Jaen, J.; Tran, L.; Vacca, J.P.; Zhuang, L.; Egbertson, M.; Medina, J.C.; Melamed, J.; Clark, D.L.; Fisher, T.E.; Langford, M.; Wai, J.S.; Payne, L.S.; Embrey, M.W.; Young, S.D. (Merck & Co., Inc.; Tularik Inc.)
来源:	WO 9962520

合成路线图解说明: Claisen condensation of 3',5'-bis(benzyloxy)acetophenone (I) with dimethyl oxalate or diethyloxalate in the presence of NaH in refluxing DME yielded diketo ester (II). Basic hydrolysis of the methyl ester group of (I) then furnished the title carboxylic acid.

参考文献No.	683802
标题:	Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors
作者:	Pais, G.C.G.; Zhang, X.; Marchand, C.; Neamati, N.; Cowansage, K.; Svarovskaia, E.S.; Pathak, V.K.; Tang, Y.; Nicklaus, M.; Pommier, Y.; Burke, T.R. Jr.
来源:	J Med Chem 2002,45(15),3184

合成路线图解说明: Claisen condensation of 3',5'-bis(benzyloxy)acetophenone (I) with dimethyl oxalate or diethyloxalate in the presence of NaH in refluxing DME yielded diketo ester (II). Basic hydrolysis of the methyl ester group of (I) then furnished the title carboxylic acid.