Piperacillin-药物合成数据库

【药物名称】Piperacillin

化学结构式(Chemical Structure):

参考文献No.	800605
标题:	Piperacillin
作者:	Loren, J.G.; Casta馿r, J.
来源:	Drugs Fut 1978,3(11),829

合成路线图解说明: The cyclization of diethyl oxalate (I) with N-ethylethylenediamine (II) in ethanol gives ethyl-2,3-dioxopiperazine (III), which by reaction first with trimethylsilyl chloride and triethytamine and then with phosgene in THF is converted into 4-ethyl-2,3-dioxopiperazine-1-carboxylic acid chloride (IV). Finally, this compound is condensed with 6-D-(-)-alpha-aminophenylacetamidopenicillanic acid (V) by means of triethylamine in THF - water.

参考文献No.	800606
标题:	Penicillins and cephalosporins and process for producing the same
作者:	Saikawa, I.; et al.
来源:	DE 2519400; FR 2269937; FR 2320295; GB 1508062

合成路线图解说明: The cyclization of diethyl oxalate (I) with N-ethylethylenediamine (II) in ethanol gives ethyl-2,3-dioxopiperazine (III), which by reaction first with trimethylsilyl chloride and triethytamine and then with phosgene in THF is converted into 4-ethyl-2,3-dioxopiperazine-1-carboxylic acid chloride (IV). Finally, this compound is condensed with 6-D-(-)-alpha-aminophenylacetamidopenicillanic acid (V) by means of triethylamine in THF - water.