BOM-1006-药物合成数据库

【药物名称】BOM-1006

化学结构式(Chemical Structure):

参考文献No.	561136
标题:	Synthesis of benzimidazole derivatives as antiallergic agents with 5-lipoxygenase inhibiting action
作者:	Nakano, H.; Inoue, T.; Kawasaki, N.; Miyataka, H.; Matsumoto, H.; Taguchi, T.; Inagaki, N.; Nagai, H.; Satoh, T.
来源:	Chem Pharm Bull 1999,47(11),1573

合成路线图解说明: 2-Chlorobenzimidazole (I) was treated with NaH in DMF and the resulting sodium salt was alkylated with 4-[2-(2-chloroethoxy)ethoxy]-2,3,6-trimethylphenol (II) to give (III). Subsequent displacement of the chlorine of (III) with N-methyl homopiperazine (IV) at 130 C produced the desired 2-(homopiperazino)benzimidazole, which was finally treated with fumaric acid in EtOH to yield the corresponding bis fumarate salt.

参考文献No.	568743
标题:	Synthesis and biological activities of novel antiallergic agents with 5-lipoxygenase inhibiting action
作者:	Nakano, H.; Inoue, T.; Kawasaki, N.; Miyataka, H.; Matsumoto, H.; Taguchi, T.; Inagaki, N.; Nagai, H.; Satoh, T.
来源:	Bioorg Med Chem 2000,8(2),373

合成路线图解说明: 2-Chlorobenzimidazole (I) was treated with NaH in DMF and the resulting sodium salt was alkylated with 4-[2-(2-chloroethoxy)ethoxy]-2,3,6-trimethylphenol (II) to give (III). Subsequent displacement of the chlorine of (III) with N-methyl homopiperazine (IV) at 130 C produced the desired 2-(homopiperazino)benzimidazole, which was finally treated with fumaric acid in EtOH to yield the corresponding bis fumarate salt.