【药物名称】
化学结构式(Chemical Structure):
参考文献No.560989
标题:Abasic site recognition in DNA as a new strategy to potentiate the action of anticancer alkylating drugs?
作者:Belmont, P.; Jourdan, M.; Demeunynck, M.; Constant, J.F.; Garcia, J.; Lhomme, J.; Carez, D.; Croisy, A.
来源:J Med Chem 1999,42(25),5153
合成路线图解说明:

The known acridine-purine hybrid molecule (I) was converted into the Boc-protected bisguanidine derivative (III) by reaction with bis(tert-butoxycarbonyl)thiourea (II) in the presence of HgCl2 and Et3N. Subsequent acidic cleavage of the Boc groups gave the title compound.

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