【药物名称】UCL-1848
化学结构式(Chemical Structure):
参考文献No.35324
标题:Potassium channel blockers
作者:Campos-Rosa, J.; Dunn, P.M.; Galanakis, D.; Ganellin, C.R.; Jenkinson, D.H.; Yang, D.; Chen, J. (University College London)
来源:WO 9748705
合成路线图解说明:

The condensation of 1,5-diaminopentane (II) with 4-chloroquinoline (I) produced the bis-quinoline derivative (III). This was then cyclized with 1,5-diiodopentane (IV), and the resulting macrocyclic compound was purified by preparative HPLC in the presence of trifluoroacetic acid to furnish the title bis trifluoroacetate salt.

参考文献No.593348
标题:Bis-quinolinium cyclophanes: 8,14-diaza-1,7(1,4)-diquinolinacyclo-tetradecaphane (UCL 1848), a highly potent and selective, nonpeptidic blocker of the apamin-sensitive Ca2+-activated K+ channel
作者:Chen, J.-Q.; Galanakis, D.; Ganellin, C.R.; Dunn, P.M.; Jenkinson, D.H.
来源:J Med Chem 2000,43(19),3478
合成路线图解说明:

The condensation of 1,5-diaminopentane (II) with 4-chloroquinoline (I) produced the bis-quinoline derivative (III). This was then cyclized with 1,5-diiodopentane (IV), and the resulting macrocyclic compound was purified by preparative HPLC in the presence of trifluoroacetic acid to furnish the title bis trifluoroacetate salt.

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