【药物名称】CX-546
化学结构式(Chemical Structure):
参考文献No.51179
标题:Endocrine modulation with positive modulators of AMPA type glutamate receptors
作者:Van der Klish, P.; Lynch, G. (University of California, Oakland)
来源:US 6329368; WO 9850036
合成路线图解说明:

The title amide was prepared by coupling of 2,3-dihydrobenzodioxin-6-carboxylic acid (I) with piperidine (II). Carbonyldiimidazole or some chlorinating reagents, such as thionyl chloride or oxalyl chloride, were used as the carboxylate-activating reagents for the coupling reaction. Alternatively, acid (I) was previously converted to an activated mixed anhydride with either pivaloyl chloride or trifluoroacetic anhydride in the presence of triethylamine.

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