【药物名称】
化学结构式(Chemical Structure):
参考文献No.559205
标题:Synthesis and pharmacology of site-specific cocaine abuse treatment agents: The role of the phenyl group in highly modified methylphenidate analogs as dopamine uptake inhibitors
作者:Dunn, T.; Deutsch, H.M.; Schweri, M.M.; Ye, X.
来源:Med Chem Res 1999,9(4),213
合成路线图解说明:

2-Pyridyl acetic acid (I) is converted into its methyl ester derivative (II) by means of SOCl2 in MeOH and then vigorously hydrogenated over Pt in MeOH to afford 2-(2-piperidyl)acetic acid methyl (III). Finally, piperidine ester derivative (III) is alkylated on nitrogen with 2-phenylethylbromide (IV) in DMF in the presence of K2CO3.

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