【药物名称】KF-58333
化学结构式(Chemical Structure):
参考文献No.36493
标题:Radicicol derivs.
作者:Ino, Y.; Shiotsu, Y.; Amishiro, N.; Miyata, M.; Murakata, C.; Ogawa, H.; Akiyama, T.; Akinaga, S.; Soga, S. (Kyowa Hakko Kogyo Co., Ltd.)
来源:EP 0889042; US 6239168; US 6316491; WO 9818780
合成路线图解说明:

The title oxime derivative was prepared by reaction of the microbial metabolite radiciclol (I) with O-[2-(2-oxo-1-pyrrolidinyl)ethyl]hydroxylamine (II), followed by separation of the resulting mixture of E/Z isomers by preparative HPLC.

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