【药物名称】
化学结构式(Chemical Structure):
参考文献No.557413
标题:Piperidinylpyrroles: Design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands
作者:Haubmann, C.; Hubner, H.; Gmeiner, P.
来源:Bioorg Med Chem Lett 1999,9(21),3143
合成路线图解说明:

The condensation of 4-amino-1-benzylpiperidine (I) with 2,5-dimethoxytetrahydrofuran-3-carbaldehyde (II) under modified Paal-Knorr conditions produced the pyrrole derivative (III). Construction of the target oxazole ring was then achieved by cyclocondensation reaction of aldehyde (III) with tosylmethyl isocyanide in the presence of NaOMe.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us