-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	39887
标题:	C-10 carbon-substd. artemisinin-like trioxane cpds. having antimalarial, antiproliferative and antitumour activities
作者:	Parker, M.H.; Shapiro, T.A.; Ploypradith, P.; Posner, G.H.; Northrup, J.; Daughenbaugh, R.J.; Woo, S.H.; Murray, C.; Elias, J.S.; Zheng, Q.Y. (Hauser, Inc.; Johns Hopkins University)
来源:	EP 1043988; WO 9933461

合成路线图解说明: Reduction of artemisinin (I) by means of NaBH4 in THF/MeOH followed by treatment with BH3稨2O in MeOH yields (II). Finally, beta-artemether (II) is condensed with TMS-enol ether (IV) [obtained by protection of diacetylbenzene (III) by means of TMSOTf and Et3N in THF] in the presence of TiCl4 in CH2Cl2.

参考文献No.	553717
标题:	Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers
作者:	Posner, G.H.; Ploypradith, P.; Parker, M.H.; O'Dowd, H.; Woo, S.H.; Northrop, J.; Krasavin, M.; Dolan, P.; Kensler, T.W.; Xie, S.; Shapiro, T.A.
来源:	J Med Chem 1999,42(21),4275

合成路线图解说明: Reduction of artemisinin (I) by means of NaBH4 in THF/MeOH followed by treatment with BH3稨2O in MeOH yields (II). Finally, beta-artemether (II) is condensed with TMS-enol ether (IV) [obtained by protection of diacetylbenzene (III) by means of TMSOTf and Et3N in THF] in the presence of TiCl4 in CH2Cl2.