【药物名称】
化学结构式(Chemical Structure):
参考文献No.552015
标题:Synthesis and biology of 3'-N-acyl-N-debenzoylpaclitaxel analogues
作者:Roh, E.J.; Song, C.E.; Kim, D.; Pae, H.O.; Chung, H.T.; Lee, K.S.; Chai, K.B.; Lee, C.O.; Choi, S.U.
来源:Bioorg Med Chem 1999,7(9),2115
合成路线图解说明:

The condensation of trichloroacetyl-baccatin III (I) with the oxazolidine (II) by means of DCC in toluene gives the acylated baccatin (III), which is hydrolyzed with conc. HCl yielding the N-debenzoylated taxol (IV). The acylation of the free amino group of (IV) with 1-pentenylcarbonyl chloride (V) in pyridine affords the trichloroacetylated target compound (V), which is finally deprotected with ammonium acetate in MeOH/THF.

参考文献No.697464
标题:Structure-activity relationship study at the 3'-N-position of paclitaxel: synthesis and biological evaluation of 3'-N-acyl-paclitaxel analogues
作者:Roh, E.J.; Kim, D.; Lee, C.O.; Choi, S.U.; Song, C.E.
来源:Bioorg Med Chem 2002,10(10),3145
合成路线图解说明:

The condensation of trichloroacetyl-baccatin III (I) with the oxazolidine (II) by means of DCC in toluene gives the acylated baccatin (III), which is hydrolyzed with conc. HCl yielding the N-debenzoylated taxol (IV). The acylation of the free amino group of (IV) with 1-pentenylcarbonyl chloride (V) in pyridine affords the trichloroacetylated target compound (V), which is finally deprotected with ammonium acetate in MeOH/THF.

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