【药物名称】PNU-176968
化学结构式(Chemical Structure):
参考文献No.550594
标题:Carbon-carbon-linked 5-membered heteroarylphenyl oxazolidinones with broad-spectrum antibacterial activity
作者:Anderson, D.J.; Allwine, D.A.; Genin, M.J.; et al.
来源:39th Intersci Conf Antimicrob Agents Chemother (Sept 26 1999, San Francisco) 1999,Abst F570
合成路线图解说明:

Lithiation of thiazole (I) with butyllithium at -78 C, followed by quenching with chlorotrimethylsilane afforded 2-(trimethylsilyl)thiazole (II). A second lithiation generated the 5-lithio thiazole, which was converted to the stannyl derivative (III) upon reaction with tributylstannyl chloride. Then, palladium-catalyzed coupling of (III) with the iodophenyl oxazolidine (IV) in refluxing dioxan furnished the title compound.

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