【药物名称】S-33004((+)-enantiomer), S-32647(racemate), S-33005
化学结构式(Chemical Structure):
参考文献No.40460
标题:Benzocyclobutan cpds., their process for preparation and pharmaceutical compsns. containing them
作者:Brocco, M.; Harmange, J.-C.; Peglion, J.-L.; Dessinges, A.; Newman-Tancredi, A.; Millan, M. (ADIR et Cie.)
来源:CA 2264372; EP 0940386; FR 2775687; JP 1999310557; US 6107345
合成路线图解说明:

Lithiation of 1-cyano-5-methoxybenzocyclobutane (I), followed by addition of cyclohexanone (II), provided the 1-hydroxycyclohexyl adduct (III). The cyano group of (III) was then reduced to amine (IV) using LiAlH4. Reductive alkylation of amine (IV) with formaldehyde and NaBH3CN furnished the corresponding dimethylamino derivative, which was then converted to the corresponding hydrochloride salt with ethereal HCl.

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