【药物名称】
化学结构式(Chemical Structure):
参考文献No.552678
标题:Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors
作者:Dumas, J.; Britelli, D.; Chen, J.; Dixon, B.; Hatoum-Mokdad, H.; K鰊ig, G.; Sibley, R.; Witowsky, J.; Wong, S.
来源:Bioorg Med Chem Lett 1999,9(17),2531
合成路线图解说明:

The condensation of mercapto benzothiazole (I) with 4-fluoronitrobenzene (II) afforded the 4-nitrophenyl thioether (III). After reduction of the nitro group of (III) with iron in HOAc, the resulting aniline (IV) was acylated with the dichloroisatoic anhydride (V) to produce the anthranylamide (VI). This was finally condensed with 3,5-dichloro-2-hydroxybenzenesulfonyl chloride (VII) to yield the corresponding sulfonamide.

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