FTI-2148-药物合成数据库

【药物名称】FTI-2148

化学结构式(Chemical Structure):

参考文献No.	616316
标题:	Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine
作者:	Sun, J.; Blaskovich, M.A.; Knowles, D.; Qian, Y.; Ohkanda, J.; Bailey, R.D.; Hamilton, A.D.; Sebti, S.M.
来源:	Cancer Res 1999,59(19),4919

合成路线图解说明: Reductive amination of the methionine methyl ester adduct of 2-(2-methylphenyl)-4-aminomethyl benzoic acid (I) with 1-trityl-4-formylimidazole (II) gave the secondary amine (III). After trityl group deprotection, the resultant methyl ester (IV) was hydrolyzed to the target carboxylic acid by using LiOH.