DF-1-药物合成数据库

【药物名称】DF-1

化学结构式(Chemical Structure):

参考文献No.	546069
标题:	New type of febrifugine analogues, bearing a quinolizidine moiety, show potent antimalarial activity against Plasmodium malaria parasite
作者:	Takaya, Y.; Tasaka, H.; Chiba, T.; Uwai, K.; Tanitsu, M.; Kim, H.S.; Wataya, Y.; Miura, M.; Takeshita, M.; Oshima, Y.
来源:	J Med Chem 1999,42(16),3163

合成路线图解说明: By cyclization of febrifugine (I) with acetone over SiO2.

合成路线图解说明: The isomerization of febrifugine (I) by means of HCl in methanol gives isofebrifugine (II), which is then cyclized with acetone over SiO2.