-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	40113
标题:	Tissue specific prodrug
作者:	Christensen, S.B.; Issacs, J.T.; Denmeade, S.R.; Lilja, H. (Johns Hopkins University)
来源:	WO 9852966

合成路线图解说明: 8-O-Debutanoylthapsigargin (II) was obtained by triethylamine-catalyzed methanolysis of thapsigargin (I). Coupling of (II) with N-Boc-4-aminocinnamic acid (III) in the presence of DCC and DMAP provided ester (IV). The Boc protecting group of (IV) was then cleaved by treatment with trifluoroacetic acid.

参考文献No.	545857
标题:	Thapsigargin analogues for targeting programmed death of androgen-independent prostate cancer cells
作者:	Christensen, S.B.; Andersen, A.; Kromann, H.; Treiman, M.; Tombal, B.; Denmeade, S.; Isaacs, J.T.
来源:	Bioorg Med Chem 1999,7(7),1273

合成路线图解说明: 8-O-Debutanoylthapsigargin (II) was obtained by triethylamine-catalyzed methanolysis of thapsigargin (I). Coupling of (II) with N-Boc-4-aminocinnamic acid (III) in the presence of DCC and DMAP provided ester (IV). The Boc protecting group of (IV) was then cleaved by treatment with trifluoroacetic acid.