【药物名称】PAT-5A
化学结构式(Chemical Structure):
参考文献No.40220
标题:Heterocyclic cpds. having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compsns. containing them
作者:Rao, P.B.; Ramanujam, R.; Alla, S.R.; Lohray, V.B.; Chakrabarti, R.; Lohray, B.B. (Dr. Reddy's Research Foundation)
来源:US 5919782
合成路线图解说明:

2-Chloropyridine (I) was condensed with (S)-prolinol (II) to furnish the pyridinylpyrrolidine (III). Subsequent alkylation of the hydroxyl group of (III) with 4-fluorobenzaldehyde (IV) using NaH in hot DMF gave ether (V). Knoevenagel condensation of (V) with 2,4-thiazolidinedione (VI) in the presence of benzoic acid and piperidine afforded the required benzylidene thiazolidine, which was finally treated with maleic acid in acetone to yield the title maleate salt.

参考文献No.40221
标题:Thiazolidinedione cpds. having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compsns. thereof
作者:Ramanujam, R.; Lohray, B.B.; Alla, S.R.; Chakrabarti, R.; Paraselli, R.B.; Lohray, V.B. (Dr. Reddy's Research Foundation)
来源:WO 9741120
合成路线图解说明:

2-Chloropyridine (I) was condensed with (S)-prolinol (II) to furnish the pyridinylpyrrolidine (III). Subsequent alkylation of the hydroxyl group of (III) with 4-fluorobenzaldehyde (IV) using NaH in hot DMF gave ether (V). Knoevenagel condensation of (V) with 2,4-thiazolidinedione (VI) in the presence of benzoic acid and piperidine afforded the required benzylidene thiazolidine, which was finally treated with maleic acid in acetone to yield the title maleate salt.

参考文献No.545062
标题:Novel euglycemic and hypolipidemic agents. 4. Pyridyl- and quinolinyl-containing thiazolidinediones
作者:Lohray, B.B.; Bhushan, V.; Reddy, A.S.; Rao, P.B.; Reddy, N.J.; Harikishore, P.; Haritha, N.; Vikramadityan, R.K.; Chakrabarti, R.; Rajagopalan, R.; Katneni, K.
来源:J Med Chem 1999,42(14),2569
合成路线图解说明:

2-Chloropyridine (I) was condensed with (S)-prolinol (II) to furnish the pyridinylpyrrolidine (III). Subsequent alkylation of the hydroxyl group of (III) with 4-fluorobenzaldehyde (IV) using NaH in hot DMF gave ether (V). Knoevenagel condensation of (V) with 2,4-thiazolidinedione (VI) in the presence of benzoic acid and piperidine afforded the required benzylidene thiazolidine, which was finally treated with maleic acid in acetone to yield the title maleate salt.

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