【药物名称】
化学结构式(Chemical Structure):
参考文献No.541734
标题:Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme
作者:Maggiora, L.L.; Orawski, A.T.; Simmons, W.H.
来源:J Med Chem 1999,42(13),2394
合成路线图解说明:

The compound was prepared by solid phase peptide synthesis on a p-methylbenzhydrylamine resin. Attachment of Boc-L-alanine (I) afforded resin (II). Subsequent deprotection of the Boc group of (II) gave the alanine-linked resin (III). Coupling of (III) with Boc-L-proline (IV), followed by Boc group cleavage yielded the dipeptide resin (V). Further coupling of (V) with N-Boc-(2S,3R)-3-amino-2-hydroxy-5-methylhexanoic acid (VI) furnished the tripeptide resin (VI). Finally, deprotection of the Boc group of (VI) and simultaneous cleavage from the resin by treatment with HF provided the title tripeptide amide.

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