【药物名称】LASSBio-341
化学结构式(Chemical Structure):
参考文献No.650610
标题:Design, synthesis and pharmacological evaluation of novel pyrazolo[3,4-b]thieno[2,3-d]pyridine acid derivatives: A new class of anti-inflammatory and anti-platelet agents
作者:Cardoso, C.R.; de Brito, F.C.F.; da Silva, K.C.M.; de Miranda, A.L.P.; Fraga, C.A.M.; Barreiro, E.J.
来源:Bioorg Med Chem Lett 2002,12(1),9
合成路线图解说明:

Condensation of the known chloro pyrazolopyridine (I) with the lithium salt of 4-chlorobenzylthiol (II) produces the intermediate thioether (III) which, in the presence of excess LDA, undergoes intramolecular Claisen condensation to the pyrazolothienopyridine derivative (IV). Subsequent acylation of (IV) with glutaric anhydride (V) in acetone gives rise to the target glutarate mono-ester.

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