NCS-706-药物合成数据库

【药物名称】NCS-706

化学结构式(Chemical Structure):

参考文献No.	737815
标题:	Design, synthesis and structure-activity relationships of a series of 9-substituted adenine derivatives as selective phosphodiesterase type-4 inhibitors
作者:	Raboisson, P.; Lugnier, C.; Muller, C.; Reimund, J.-M.; Schultz, D.; Pinna, G.; Le Bec, A.; Basaran, H.; Desaubry, L.; Gaudiot, F.; Seloum, M.; Bourguignon, J.-J.
来源:	Eur J Med Chem 2003,38(2),199

合成路线图解说明: Alkylation of 2-amino-6-chloropurine (I) with 2-methoxybenzyl chloride (II) in the presence of K2CO3 and Bu4NI gives the 9-substituted purine (III). Amino purine (III) is converted into the corresponding 2-iodo derivative (IV) by treatment with isoamyl nitrite in hot diiodomethane. Finally, displacement of the 6-chloro group of (IV) with methylamine furnishes the desired adenine derivative.