【药物名称】P32/98
化学结构式(Chemical Structure):
参考文献No.39934
标题:Process for the preparation of new dipeptidyl peptidase IV inhibitors
作者:Faust, J.; Heins, J.; Rahfeld, J.U.; Demuth, H.-U.; Steinmetzer, T.; Born, I.; Barth, A.; Neubert, K. (Martin Luther Universit鋞 Halle-Wittenberg)
来源:DD 296075
合成路线图解说明:

The condensation of N-(tert-butoxycarbonyl)-L-isoleucine (I) with thiazolidine (II) by means of isobutyl chloroformate and N-ethylmorpholine (NEM) in THF gives 3-[N-(tert-butoxycarbonyl)-L-isoleucyl]thiazolidine (III), which is deprotected with HCl and thioanisole in acetic acid.

参考文献No.539691
标题:Dipeptidyl peptidase IV in the immune system. Effects of specific enzyme inhibitors on activity of dipeptidyl peptidase IV and proliferation of human lymphocytes
作者:Sch鰊, E.; Born, I.; Demuth, H.-U.; faust, J.; Neubert, K.; Steinmetzer, T.; Barth, A.; Ansorge, S.
来源:Biol Chem Hoppe Seyler 1991,372(5),305
合成路线图解说明:

The condensation of N-(tert-butoxycarbonyl)-L-isoleucine (I) with thiazolidine (II) by means of isobutyl chloroformate and N-ethylmorpholine (NEM) in THF gives 3-[N-(tert-butoxycarbonyl)-L-isoleucyl]thiazolidine (III), which is deprotected with HCl and thioanisole in acetic acid.

参考文献No.635893
标题:P32/98
作者:Sorbera, L.A.; Revel, L.; Casta馿r, J.
来源:Drugs Fut 2001,26(9),859
合成路线图解说明:

The condensation of N-(tert-butoxycarbonyl)-L-isoleucine (I) with thiazolidine (II) by means of isobutyl chloroformate and N-ethylmorpholine (NEM) in THF gives 3-[N-(tert-butoxycarbonyl)-L-isoleucyl]thiazolidine (III), which is deprotected with HCl and thioanisole in acetic acid.

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