-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	538398
标题:	Efficient inhibition of muscle and liver glycogen phosphorylases by a new glucopyranosylidene-spiro-thiohydantoin
作者:	Osz, E.; Somsak, L.; Szilagyi, L.; Kovacs, L.; Docsa, T.; Toth, B.; Gergely, P.
来源:	Bioorg Med Chem Lett 1999,9(10),1385

合成路线图解说明: 1-Bromo-1-deoxy-beta-D-glucopyranosyl cyanide (II) was obtained by radical bromination of the corresponding glucopyranosyl cyanide (I). Partial hydrolysis of the cyanide group of (II) by means of TiCl4 in aqueous AcOH afforded amide (III). Subsequent ring closure of (III) with AgSCN or KSCN in nitromethane gave the spiro thiohydantoin (IV). The acetate esters of (IV) were finally eliminated using NaOMe in MeOH.

参考文献No.	627514
标题:	Synthesis of and a comparative study on the inhibition of muscle and liver glycogen phosphorylases by epimeric pairs of D-gluco- and D-xylopyranosyliene-spiro-(thio)hydantoins and N-(D-glucopyranosyl) amides
作者:	Soms醟, L.; Kovacs, L.; Toth, M.; Osz, E.; Szilagyi, L.; Gyorgydeak, Z.; Dinya, Z.; Docsa, T.; Toth, B.; Gergely, P.
来源:	J Med Chem 2001,44(17),2843

合成路线图解说明: 1-Bromo-1-deoxy-beta-D-glucopyranosyl cyanide (II) was obtained by radical bromination of the corresponding glucopyranosyl cyanide (I). Partial hydrolysis of the cyanide group of (II) by means of TiCl4 in aqueous AcOH afforded amide (III). Subsequent ring closure of (III) with AgSCN or KSCN in nitromethane gave the spiro thiohydantoin (IV). The acetate esters of (IV) were finally eliminated using NaOMe in MeOH.