【药物名称】Antrafenine
化学结构式(Chemical Structure):
参考文献No.47807
标题:Esters of 2-[(4-quinolyl)amino]benzoic acids
作者:Giudicelli, P.R.L.; et al. (Sanofi-Synth閘abo)
来源:DE 2415982; DE 2462460; GB 1441184; JP 50030891; US 3935229
合成路线图解说明:

By transesterification of allyl 2-(7-trifluoromethyl-4-quinolinylamino)benzoate (I) with 2-[4-(m-trifluoromethylphenyl)-1-piperazinyl]ethanol (II) in refluxing toluene.

参考文献No.604965
标题:Synthesis and analgesic activity of some anthranilic acid derivatives
作者:Manoury, Ph.; et al.
来源:5th Int Symp Med Chem 1976,Abst 074
合成路线图解说明:

By transesterification of allyl 2-(7-trifluoromethyl-4-quinolinylamino)benzoate (I) with 2-[4-(m-trifluoromethylphenyl)-1-piperazinyl]ethanol (II) in refluxing toluene.

参考文献No.800661
标题:Antrafenine
作者:Casta馿r, J.; Blancafort, P.
来源:Drugs Fut 1977,2(12),786
合成路线图解说明:

By transesterification of allyl 2-(7-trifluoromethyl-4-quinolinylamino)benzoate (I) with 2-[4-(m-trifluoromethylphenyl)-1-piperazinyl]ethanol (II) in refluxing toluene.

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