【药物名称】MS-31-038
化学结构式(Chemical Structure):
参考文献No.30705
标题:Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical compsns. containing the cpds.
作者:Fujiwara, J.; Mori, H.; Yamashita, H.; Kitamori, T.; Hosoya, J.; Banno, H. (Mitsui Chemicals, Inc.)
来源:EP 0726254; JP 1996277269; US 5627193
合成路线图解说明:

Quinoline (IV) was prepared by condensation of 3,5-dimethoxyaniline (I), pyruvic acid (II) and o-tolualdehyde (III) in refluxing EtOH. After activation of (IV) as the acid chloride (V) by means of SOCl2 in benzene, its condensation with guanidine (VI) in DMF yielded the corresponding acyl guanidine.

合成路线图解说明:

Quinoline (IV) was prepared by condensation of 2-(2-methoxyethyl)aniline (I), pyruvic acid (II) and benzaldehyde (III) in refluxing EtOH. After activation of (IV) as the imidazolide (V) by means of 1,1'-carbonyldiimidazole in DMF, its condensation with guanidine (VI) in the same solvent yielded the corresponding acyl guanidine.

参考文献No.560567
标题:MS-31-038
作者:Kitamori, T.; Hosoya, J.; Mori, H.; Banno, H.; Kibayashi, K.; Yamashita, H.; Fujiwara, J.
来源:Drugs Fut 1999,24(12),1306
合成路线图解说明:

Quinoline (IV) was prepared by condensation of 2-(2-methoxyethyl)aniline (I), pyruvic acid (II) and benzaldehyde (III) in refluxing EtOH. After activation of (IV) as the imidazolide (V) by means of 1,1'-carbonyldiimidazole in DMF, its condensation with guanidine (VI) in the same solvent yielded the corresponding acyl guanidine.

参考文献No.800096
标题:Ueber alpha-alkylcinchoninsauren
作者:Doebner, O.
来源:Ber 1887,20277-80
合成路线图解说明:

Quinoline (IV) was prepared by condensation of 2-(2-methoxyethyl)aniline (I), pyruvic acid (II) and benzaldehyde (III) in refluxing EtOH. After activation of (IV) as the imidazolide (V) by means of 1,1'-carbonyldiimidazole in DMF, its condensation with guanidine (VI) in the same solvent yielded the corresponding acyl guanidine.

参考文献No.800097
标题:Chinolinederivate aus isatinsaure
作者:Pfitzinger, W.
来源:J Prakt Chem 1886,33100
合成路线图解说明:

Quinoline (IV) was prepared by condensation of 2-(2-methoxyethyl)aniline (I), pyruvic acid (II) and benzaldehyde (III) in refluxing EtOH. After activation of (IV) as the imidazolide (V) by means of 1,1'-carbonyldiimidazole in DMF, its condensation with guanidine (VI) in the same solvent yielded the corresponding acyl guanidine.

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