【药物名称】GR-891
化学结构式(Chemical Structure):
参考文献No.39069
标题:New uracil derivs. having an anti-tumour activity and related cpds. (N-1 derivs. of 5-substd.-uracile)
作者:Campos Rosa, J.; Gallo Mezo, M.A.; Dominguez Senglar, J.F.; Entrena Guadix, A.; Pineda de las Infantas y Villatoro, M.J.; Camacho Quesada, E.; Espinosa Ubeda, A. (Universidad de Granada)
来源:WO 9117147
合成路线图解说明:

By reaction of 5-isopropoxy-1,4-dioxepane (I) with 5-fluorouracil (II) by means of SnCl4, hexamethyldisilazane (HMDS) and trimethylchlorosilane (TCS) in acetonitrile.

参考文献No.536879
标题:Diheterocyclanes as synthons for the preparation of novel series of nucleoside and acyclonucleoside analogues
作者:Campos, J.; Gomez, J.A.; Trujillo, M.A.; Gallo, M.A.; Espinosa, A.; Marchal, J.A.; Aranega, A.
来源:Farmaco 1997,52(5),263
合成路线图解说明:

By reaction of 5-isopropoxy-1,4-dioxepane (I) with 5-fluorouracil (II) by means of SnCl4, hexamethyldisilazane (HMDS) and trimethylchlorosilane (TCS) in acetonitrile.

参考文献No.536881
标题:A facile synthetic method for pyrimidine acyclonucleoside analogues from alkoxy-1,4-diheterocycloheptanes
作者:Gallo, M.A.; et al.
来源:Synlett 1993,(6),389
合成路线图解说明:

By reaction of 5-isopropoxy-1,4-dioxepane (I) with 5-fluorouracil (II) by means of SnCl4, hexamethyldisilazane (HMDS) and trimethylchlorosilane (TCS) in acetonitrile.

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