【药物名称】MPB-27
化学结构式(Chemical Structure):
参考文献No.35865
标题:CFTR channel activator cpds. and pharmaceutical compsns. containing same
作者:Becq, F.; Mettey, Y.; Vierfond, J.-M.; Verrier, B.; Gola, M. (CNRS (Centre National de la Recherche Scientifique))
来源:EP 0937044; WO 9805642
合成路线图解说明:

The condensation of 2-methylpyridine (I) with 2,3-dichlorobenzonitrile (II) by means of BuLi and diisopropylamine in THF gives the vinyl derivative (III), which is cyclized by heating at 200 C.

合成路线图解说明:

The condensation of 2-methylpyridine (I) with 2,6-dichlorobenzonitrile (II) by means of BuLi and diisopropylamine in THF gives the vinyl derivative (III), which is cyclized by heating at 200 C.

参考文献No.413992
标题:Benzo[c]quinoliziums: A new family of inhibitors for protein kinase CK II
作者:Mettey, Y.; Vierfond, J.-M.
来源:Bioorg Med Chem Lett 1997,7(8),961
合成路线图解说明:

The condensation of 2-methylpyridine (I) with 2,3-dichlorobenzonitrile (II) by means of BuLi and diisopropylamine in THF gives the vinyl derivative (III), which is cyclized by heating at 200 C.

合成路线图解说明:

The condensation of 2-methylpyridine (I) with 2,6-dichlorobenzonitrile (II) by means of BuLi and diisopropylamine in THF gives the vinyl derivative (III), which is cyclized by heating at 200 C.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us