Orpanoxin, F-776-药物合成数据库

【药物名称】Orpanoxin, F-776

化学结构式(Chemical Structure):

参考文献No.	47595
标题:	3-(5-aryl-2-furyl)-3-hydroxypropionic acids and ethyl esters
作者:	Pelosi, S.S. Jr. (Norwich Eaton)
来源:	DE 2637596; ES 448530; FR 2321286; GB 1479264; US 3962284

合成路线图解说明: The condensation of 5-(4-chlorophenyl)-2-furaldehyde (I) with ethyl bromoacetate (A) by means of Zn in benzene gives ethyl 5-(4-chlorophenyl)-beta-hydroxy-2-furanpropanoate (II), which is then hydrolyzed with NaOH in refluxing aqueous ethanol.

参考文献No.	800603
标题:	Orpanoxin
作者:	Casta馿r, J.; Blancafort, P.
来源:	Drugs Fut 1978,3(12),888

合成路线图解说明: The condensation of 5-(4-chlorophenyl)-2-furaldehyde (I) with ethyl bromoacetate (A) by means of Zn in benzene gives ethyl 5-(4-chlorophenyl)-beta-hydroxy-2-furanpropanoate (II), which is then hydrolyzed with NaOH in refluxing aqueous ethanol.