【药物名称】Tafluposide, F-11782
化学结构式(Chemical Structure):
参考文献No.29920
标题:Water-soluble epipodophyllotoxin derivs., preparation method therefor, and use thereof as a drug and for treating cancer
作者:Imbert, T.; Guminski, Y.; Monse, B.; Hill, B.; Robin, J.-P. (Pierre Fabre M閐icament)
来源:FR 2725990; JP 1998507462; US 6107284; WO 9612727
合成路线图解说明:

Pentafluorophenoxyacetic acid (I) was converted to acid chloride (II) upon treatment with oxalyl chloride, and then condensed with 4'-(benzyloxycarbonyl)etoposide (III) to give diester (IV). Subsequent hydrogenolysis of the benzyloxycarbonyl protecting group of (IV) over Pd/C provided phenol (V). Finally, reaction of (V) with phosphoryl chloride, followed by aqueous work-up yielded the target phosphate.

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