【药物名称】13-Deoxydoxorubicin hydrochloride, 13-deoxyadriamycin hydrochloride, GPX-100
化学结构式(Chemical Structure):
参考文献No.38560
标题:13-Deoxyanthracycline derivs. and processes for preparing them
作者:Olson, R.D.; Zhang, X.; Walsh, G.M. (Gem Pharmaceuticals, Inc.)
来源:EP 1011687; JP 2001515040; WO 9908687
合成路线图解说明:

Adriamycin hydrochloride (I) was converted to the tosylhydrazone (II) upon treatment with p-toluenesulfonylhydrazide in methanol. Subsequent reduction of the hydrazone functionality of (II) by means of sodium cyanoborohydride in the presence of p-toluenesulfonic acid furnished the title deoxygenated Adriamycin.

参考文献No.639179
标题:Adriamycin analogues. 2. Synthesis of 13-deoxyanthracyclines
作者:Smith, T.H.; Fujiwara, A.N.; Henry, D.W.
来源:J Med Chem 1978,21(3),280
合成路线图解说明:

Adriamycin hydrochloride (I) was converted to the tosylhydrazone (II) upon treatment with p-toluenesulfonylhydrazide in methanol. Subsequent reduction of the hydrazone functionality of (II) by means of sodium cyanoborohydride in the presence of p-toluenesulfonic acid furnished the title deoxygenated Adriamycin.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us