-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	526185
标题:	Indolylquinoline derivatives are cytotoxic to Leishmania donovani promastigotes and amastigotes in vitro and are effective in treating murine visceral leishmaniasis
作者:	Chakrabarti, G.; Basu, A.; Manna, P.P.; Mahato, S.B.; Mandal, N.B.; Bandyopadhyay, S.
来源:	J Antimicrob Chemother 1999,43(3),359

合成路线图解说明: Treatment of an excess of indole (I) with dichloroacetyl chloride (II) in the presence of AlCl3 under Friedel-Crafts conditions produced the trimer intermediate (III), which was cyclized and acylated to yield the title indolyl quinoline.

合成路线图解说明: Treatment of an excess of indole (I) with chloroacetyl chloride (II) in the presence of AlCl3 under Friedel-Crafts conditions produced the trimer intermediate (III), which was cyclized and acylated to yield the title indolyl quinoline.

参考文献No.	526187
标题:	Synthesis of indolylquinolines under Friedel-Crafts reaction conditions
作者:	Mahato, S.B.; et al.
来源:	Tetrahedron 1994,50(36),10803

合成路线图解说明: Treatment of an excess of indole (I) with dichloroacetyl chloride (II) in the presence of AlCl3 under Friedel-Crafts conditions produced the trimer intermediate (III), which was cyclized and acylated to yield the title indolyl quinoline.

合成路线图解说明: Treatment of an excess of indole (I) with chloroacetyl chloride (II) in the presence of AlCl3 under Friedel-Crafts conditions produced the trimer intermediate (III), which was cyclized and acylated to yield the title indolyl quinoline.