【药物名称】
化学结构式(Chemical Structure):
参考文献No.523553
标题:Flavonoid-related modulators of multidrug resistance: Synthesis, pharmacological activity, and structure-activity relationships
作者:Fert? J.; K黨nel, J.-M.; Chapuis, G.; Rolland, Y.; Lewin, G.; Schwaller, M.A.
来源:J Med Chem 1999,42(3),478
合成路线图解说明:

The reductocondensation of 2,3,4-trimethoxybenzaldehyde (I) with ethyl piperazine-1-carboxylate (II) by means of NaBH3CN in AcOH gives the corresponding benzyl derivative (III), which is decarboxylated with aqueous KOH at 130 C yielding 1-(2,3,4-trimethoxybenzyl)piperazine (IV). The acylation of (IV) with chloroacetyl chloride in dichloromethane affords 1-(2-chloroacetyl)-4-(2,3,4-trimethoxybenzyl)piperazine (V)., which is finally condensed with diosmetin (VI) by means of KHCO3 in DMF.

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