-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	487978
标题:	N-[2,2-Dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-L-phenylalanine ethyl ester as a stable ester-type inhibitor of chymotrypsin-like serine proteases: Structural requirements for potent inhibition of alpha-chymotrypsin
作者:	Iijima, K.; Katada, J.; Yasuda, E.; Uno, I.; Hayashi, Y.
来源:	J Med Chem 1999,42(2),312

合成路线图解说明: The condensation of ethyl isobutyrate (I) with ethanal and trimethylsilylamine in THF gives the azetidinone (III), which is treated with 4-cyanobenzoic acid succinimidyl ester (IV) in DMF yielding 3-(4-cyanobenzamido)-2,2-dimethylnonanoic acid (V). Finally, this compound is condensed with L-phenylalanine ethyl ester (VI) by means of DEC and HOBT in dichloromethane.