【药物名称】CI-1040, PD-184352
化学结构式(Chemical Structure):
参考文献No.38195
标题:4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivs. and their use as MEK inhibitors
作者:Tecle, H.; Dudley, D.T.; Bridges, A.J.; Barrett, S.D.; Saltiel, A.R.; Doherty, A.M. (Pfizer Inc.)
来源:EP 0993439; WO 9901426
合成路线图解说明:

The condensation of 2,3,4-trifluorobenzoic acid (I) with 2-chloro-4-iodoaniline (II) in the presence of LDA in THF afforded the aryl anthranilic acid (III), which was then coupled with O-(cyclopropylmethyl)hydroxylamine (IV) using bromo-tris(pyrrolidino)phosphonium hexafluorophosphate (PyBrOP) to furnish the title hydroxamate.

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