【药物名称】91/146
化学结构式(Chemical Structure):
参考文献No.529547
标题:Syntheses of 2-pyrone derivatives
作者:Tominaga, Y.; et al.
来源:Heterocycles 1976,4(9),1493
合成路线图解说明:

Title pyrone was prepared by cyclization of p-bromoacetophenone (I) with methyl 2-cyano-3,3-bis(methylthio)propenoate (II) in the presence of KOH in DMF at r.t.

参考文献No.529549
标题:Synthetic and mass spectral fragmentation studies on trisubstituted 2H-pyran-2-ones and comparative EIMS behaviour of biologically active 3,5-disubstituted pyrazoles and isoxazoles
作者:Parmar, V.S.; et al.
来源:Indian J Chem 1997,36B(10),872
合成路线图解说明:

Title pyrone was prepared by cyclization of p-bromoacetophenone (I) with methyl 2-cyano-3,3-bis(methylthio)propenoate (II) in the presence of KOH in DMF at r.t.

参考文献No.529551
标题:Ring transformation reaction: Part II - Reaction specificity of hydrazines towards 6-aryl-4-(methylthio)-2-oxo-2H-pyran-3-carbonitriles and corresponding 3-ethyl carboxylate
作者:Ram, V.J.; et al.
来源:Indian J Chem 1993,32B(9),924
合成路线图解说明:

Title pyrone was prepared by cyclization of p-bromoacetophenone (I) with methyl 2-cyano-3,3-bis(methylthio)propenoate (II) in the presence of KOH in DMF at r.t.

参考文献No.529553
标题:Synthesis and reactions of 6-aryl- and 6-styryl-3-cyano-4-methylthio-2H-pyran-2-ones
作者:Tominaga, Y.; et al.
来源:Chem Pharm Bull 1984,32(9),3384
合成路线图解说明:

Title pyrone was prepared by cyclization of p-bromoacetophenone (I) with methyl 2-cyano-3,3-bis(methylthio)propenoate (II) in the presence of KOH in DMF at r.t.

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