【药物名称】K-10085
化学结构式(Chemical Structure):
参考文献No.37896
标题:Novel cyclic diamine cpds. and medicine containing the same
作者:Kawamine, K.; Miura, T.; Shibuya, K.; Ozaki, C.; Sato, Y.; Edano, T.; Hirata, M. (Kowa Co., Ltd.)
来源:EP 0987254; WO 9854153
合成路线图解说明:

This compound was prepared by condensation of N-[2,4-bis(methylthio)-6-methylpyridin-3-yl]-2-bromoacetamide (I) with 1-[2-(oxazolo[4,5-b]pyridin-2-ylsulfanyl)ethyl]piperazine bis(trifluoroacetate) (II) using K2CO3 and a crown ether in hot DMF.

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