【药物名称】ACEA
化学结构式(Chemical Structure):
参考文献No.483852
标题:Novel analogues of arachidonylethanolamide (anandamide): Affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability
作者:Lin, S.; Khanolkar, A.D.; Fan, P.; Goutopoulos, A.; Qin, C.; Papahadjis, D.; Makriyannis, A.
来源:J Med Chem 1998,41(27),5353
合成路线图解说明:

Title compound was prepared by formation of the arachidonic acid chloride (II) upon treatment of the corresponding acid (I) with oxalyl chloride in CH2Cl2 containing DMF at 0 C, followed by condensation with propargylamine (III).

合成路线图解说明:

Title compound was prepared by formation of the arachidonic acid chloride (II) upon treatment of the corresponding acid (I) with oxalyl chloride in CH2Cl2 containing DMF at 0 C, followed by condensation with 2-chloroethylamine - HCl (III) in the presence of pyridine.

参考文献No.539998
标题:Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)
作者:Hillard, C.J.; Manna, S.; Greenberg, M.J.; Dicamelli, R.; Ross, R.A.; Stevenson, L.A.; Murphy, V.; Pertwee, R.G.; Campbell, W.B.
来源:J Pharmacol Exp Ther 1999,289(3),1427
合成路线图解说明:

Arachidonic acid (I) was converted to the mixed anhydride (II) upon treatment with isobutyl chloroformate and triethylamine. Subsequent condensation of (II) with 2-chloroethylamine (III) provided the target amide.

合成路线图解说明:

Arachidonic acid (I) was converted to the mixed anhydride (II) upon treatment with isobutyl chloroformate and triethylamine. Subsequent condensation of (II) with cyclopropylamine (III) provided the target amide.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us