【药物名称】ONO-8711
化学结构式(Chemical Structure):
参考文献No.37771
标题:Benzenesulfonamide cpds.
作者:Maruyama, T.; Nagao, Y.; Ohuchida, S. (Ono Pharmaceutical Co., Ltd.)
来源:EP 0878465; JP 1999029548; JP 2000103778
合成路线图解说明:

The known 6-[3-(aminomethyl)bicyclo[2.2.2]octan-2-yl]-5Z-hexenoic acid methyl ester (I) was acylated with 4-chloro-2-methylbenzenesulfonyl chloride (II) to produce the corresponding sulfonamide (III). Hydrolysis of the methyl ester of (III) employing NaOH furnished the title carboxylic acid.

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