【药物名称】
化学结构式(Chemical Structure):
参考文献No.478957
标题:Syntheses of new isodethiaazacephems as potent antibacterial agents
作者:Hwu, J.R.; Tsay, S.-C.; Hakimelahi, S.
来源:J Med Chem 1998,41(24),4681
合成路线图解说明:

The racemic cis-beta-lactam mesylate (I) was treated with NaN3 in DMF to give azide (II). Catalytic hydrogenation of (II) over Pd/C produced reduction to amine with concomitant cyclization to furnish the bicyclic compound (III). Further condensation of (III) with trifluoromethanesulfonyl chloride and pyridine provided a 3:1 mixture of triflates (IV) and (V). After chromatographic isolation of the required triflate (IV), deprotection of its benzyl ester by hydrogenolysis in the presence of PdCl2 yielded the title compound.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us