【药物名称】Ipamorelin, NSAC, NNC-26-0161
化学结构式(Chemical Structure):
参考文献No.482945
标题:C-14-labelling of ipamorelin, a growth hormone secretagogue
作者:Muller, L.; et al.
来源:J Label Compd Radiopharm 1998,41(12),1093
合成路线图解说明:

The successive condensations of fluorenylmethoxycarbonyl-Rink amide resin (I) with Nalpha-FMOC-Nepsilon-Boc-L-lysine (II), FMOC-D-phenylalanine (IV), FMOC-D-2-naphthylalanine (VI), FMOC-Npi-trityl-L-histidine (VIII), and finally 2-(tert-butoxycarbonylamino)isobutyric acid (X), using the solid phase peptide technique synthesis yielded resins (III), (V), (VII), (IX) and finally (XI). This last resin was then treated with trifluoroacetic acid in order to eliminate the Boc protecting groups and the solid phase resin and isolate the target compound.

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