【药物名称】RIG-200
化学结构式(Chemical Structure):
参考文献No.37632
标题:Nitric oxide donor drugs
作者:Butler, A.R.; Megson, I.L.; Greig, I.R. (University of St. Andrews)
来源:WO 9820015
合成路线图解说明:

Condensation of glucosamine (I) with anisaldehyde (II) gave imine (III). Subsequent acetylation of (III) with Ac2O in pyridine produced the tetra O-acetate (IV). The imine group of (IV) was then hydrolyzed with HCl in aqueous acetone to afford, after basic work-up, glucosamine tetraacetate (V), which was coupled with N-acetyl penicillamine using 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate to yield amide (VII). Finally, nitrosation of the mercapto group of (VII) with NaNO2 and HCl furnished the title compound.

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